A "bit" niche, but I can imagine this in a Jim Culver deck with either a lot of token control or using Mind's Eye, Ritual Candles, or other skills to boost your skill value (since the investigation is still an intellect test). If the investigated location's shroud is 3 or less it might be worth trying to fish for your skull with this card.

I asked to FFG and got the some answer. Questions is like below.

1. is it immune to attack ability from the weapon asset? so it means impossible to take fight action on weapon?
2. is it immune to commit attributes? like if player do basic fight ability against to Feline and commit the Overpower then is it take 2 strength from Overpower or not?
3. is it immune to damage boost cards? like if i take basic action and commit the vicious blow and success then is it take damage 1 or 2?
4. if it is not immune to vicious blow then how about like longshot that cards says deal damage (not the attack damage boost)

Answer is like below The Feline Hybrid cannot be targeted by player card effects, which means it can’t be targeted by a Fight ability or a damage-dealing ability on a player card. However, an investigator can take a basic fight action targeting the Hybrid and commit cards with effects that increase their own stats or damage output for the test. So yes, Vicious Blow can cause the investigator to deal additional damage to the Hybrid, but Long Shot cannot deal damage to the Hybrid.

As much as I love playing Isabelle, I seriously wonder who thought giving Isabelle Barnes a copy of Thompson Submachine Gun as her signature card AND Gift of Nodens built into her investigator sheet was a good idea.

To be clear, Isabelle's Twin .45s takes some setup. It's not self-sufficient, and Isabelle's base stats mean you're only fighting at 4 for each attack. The extra Fight action also requires Isabelle to fight with Agility, so you may not have skill dedications for both halves of the card.

On the other hand, Resourceful, At a Crossroads, and Fight or Flight exist to help Isabellle break the game in half. Assuming you have time for setup, you can play Fight or Flight to get a massive boost to each fight action, and sequence your Resourceful to recur At a Crossroads to get extra actions --- easily allowing you to fight at 9+ six times in a row and do 12 damage. Most enemies will just explode. If you really need to reset and do it all over again, just make sure to have Hunter's Instinct and Act of Desperation available, and you can chuck your guns at the boss as a coup de grace, and then reset to do it all over again.

This card seems to be much stronger than the two other "do powerful effect, then you are defeated" cards in the game. The way I see it, if you play this card and then you resign before (!) the repetition of the investigation phase ends, you avoid being defeated and suffering trauma, since you're no longer in the game when the "you are defeated" part of the effect resolves. If I'm correct about this, then this is a very strong card!

Do-or-Die is just Resourceful, but slightly more restrictive and with different icon. Instead of being able to return any Survivor card that is not named Resourceful, Do-or-Die can only be used to recur Asset and Event Survivor cards. That might sound like a major issue, but you barely notice it with cards like Gift of Nodens and the new Hunter's Instinct.