Is... Is that Taylor Swift in the art?
As much as I like Panic, Stupor, and Arm/Leg Injury from a mechanics perspective, they feel both flavorful and balanced, I feel like running an all soak no healing style deck hamstrings anyone that happens to pull one of these as a random weakness.
Barring something like Doomed or Offer You Cannot Refuse or maybe Through the Gates hitting something important, I feel like most basic weaknesses can be dealt with by anyone... even if it's devastating to the bearer (like Drawing the Sign with Harvey Walters or Paranoia in a big money deck). Harvey probably isn't happy to see Drawing the Sign pop out, but he can still toss it and move on rebuilding his hand. But if you happen to be running someone like Tommy Muldoon relying almost entirely on asset soak instead of healing getting one of these weaknesses cripples you from the moment you draw it to the end of that scenario. In my opinion how you feel about these weaknesses entirely depends on what kind of deck you're playing when you get them. Getting Panic or Stupor in a Carolyn deck probably doesn't bother you (I assume that since you can heal it as if it was horror it would still trigger her ability) as you can just treat it as "Miss a draw, take 1 fake horror, and maybe have to restructure your next turn or two if you're unlucky" but a soak heavy no healing Tommy deck likely has to pick up a new card to compensate for the newfound gaping wound in their arm, leg, or psyche.
Thematically these weaknesses are very flavorful and mechanically interesting, I just wouldn't want to be stuck in the middle of the Antarctic without a Medical Student or First Aid kit. Peter Sylvestre and Jessica Hyde just have to sit there and watch you bleed and panic since the "horror" or "damage" is on you, not them.